Caspase 5 Inhibitors Search Results


caspase-5 inhibitor carboxybenzoxy-trp-glu-his-asp-fluoromethylketone (z-wehd-fmk  (Enzo Biochem)
90
Enzo Biochem caspase-5 inhibitor carboxybenzoxy-trp-glu-his-asp-fluoromethylketone (z-wehd-fmk
Secretion of IL-1β in response to live and UV-inactivated HCMV requires the AIM2 inflammasome. (A) Immunoblot assay for caspase-1, ASC, NLRP3, IFI16, AIM2, and GAPDH in THP-1 cells transduced with Cas9 and guide RNA (gRNA) targeting HUMCYC pseudogene or in indicated CRISPR-generated knockout cells. (B) IL-1β secretion in THP-1 cells with the HUMCYC pseudogene or gene encoding an indicated protein deleted was measured following mock treatment (white) or treatment with live (gray) or UV-inactivated (black) HCMV (HCMV-TB40/E; MOI of 3) for 18 h. Values are averages ± SEM from three biological replicates. (C) IL-1β secretion in differentiated THP-1 cells following mock treatment or treatment with UV-HCMV (UV) alone or in combination with caspase-1 inhibitor (YVAD), caspase-4 inhibitor (LEVD), <t>caspase-5</t> inhibitor (WEHD), or caspase-8 inhibitor (IETD) for 18 h. Values are averages ± SEM from three replicates. One-way ANOVA with Bonferroni correction was performed. **, P < 0.01.
Caspase 5 Inhibitor Carboxybenzoxy Trp Glu His Asp Fluoromethylketone (Z Wehd Fmk, supplied by Enzo Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/Caspase+5+Inhibitors/caspase+5+inhibitor+carboxybenzoxy+trp+glu+his+asp+fluoromethylketone++z+wehd+fmk/pmc06372796-280-8-21
Average 90 stars, based on 1 article reviews
caspase-5 inhibitor carboxybenzoxy-trp-glu-his-asp-fluoromethylketone (z-wehd-fmk - by Bioz Stars, 2026-09
90/100 stars
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z-tryptophan-glutamic acid-histidine-aspartic acid (wehd)-fmk (caspase-5 inhibitor)  (MBL Life science)
90
MBL Life science z-tryptophan-glutamic acid-histidine-aspartic acid (wehd)-fmk (caspase-5 inhibitor)
Secretion of IL-1β in response to live and UV-inactivated HCMV requires the AIM2 inflammasome. (A) Immunoblot assay for caspase-1, ASC, NLRP3, IFI16, AIM2, and GAPDH in THP-1 cells transduced with Cas9 and guide RNA (gRNA) targeting HUMCYC pseudogene or in indicated CRISPR-generated knockout cells. (B) IL-1β secretion in THP-1 cells with the HUMCYC pseudogene or gene encoding an indicated protein deleted was measured following mock treatment (white) or treatment with live (gray) or UV-inactivated (black) HCMV (HCMV-TB40/E; MOI of 3) for 18 h. Values are averages ± SEM from three biological replicates. (C) IL-1β secretion in differentiated THP-1 cells following mock treatment or treatment with UV-HCMV (UV) alone or in combination with caspase-1 inhibitor (YVAD), caspase-4 inhibitor (LEVD), <t>caspase-5</t> inhibitor (WEHD), or caspase-8 inhibitor (IETD) for 18 h. Values are averages ± SEM from three replicates. One-way ANOVA with Bonferroni correction was performed. **, P < 0.01.
Z Tryptophan Glutamic Acid Histidine Aspartic Acid (Wehd) Fmk (Caspase 5 Inhibitor), supplied by MBL Life science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/Caspase+5+Inhibitors/z+tryptophan+glutamic+acid+histidine+aspartic+acid++wehd++fmk++caspase+5+inhibitor+/pmc01782908-125-25-48
Average 90 stars, based on 1 article reviews
z-tryptophan-glutamic acid-histidine-aspartic acid (wehd)-fmk (caspase-5 inhibitor) - by Bioz Stars, 2026-09
90/100 stars
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caspase-4 and caspase-5 inhibitor acetyl-leu-glu-val-asp-cho (mw 500.6 da)  (Enzo Biochem)
90
Enzo Biochem caspase-4 and caspase-5 inhibitor acetyl-leu-glu-val-asp-cho (mw 500.6 da)
Secretion of IL-1β in response to live and UV-inactivated HCMV requires the AIM2 inflammasome. (A) Immunoblot assay for caspase-1, ASC, NLRP3, IFI16, AIM2, and GAPDH in THP-1 cells transduced with Cas9 and guide RNA (gRNA) targeting HUMCYC pseudogene or in indicated CRISPR-generated knockout cells. (B) IL-1β secretion in THP-1 cells with the HUMCYC pseudogene or gene encoding an indicated protein deleted was measured following mock treatment (white) or treatment with live (gray) or UV-inactivated (black) HCMV (HCMV-TB40/E; MOI of 3) for 18 h. Values are averages ± SEM from three biological replicates. (C) IL-1β secretion in differentiated THP-1 cells following mock treatment or treatment with UV-HCMV (UV) alone or in combination with caspase-1 inhibitor (YVAD), caspase-4 inhibitor (LEVD), <t>caspase-5</t> inhibitor (WEHD), or caspase-8 inhibitor (IETD) for 18 h. Values are averages ± SEM from three replicates. One-way ANOVA with Bonferroni correction was performed. **, P < 0.01.
Caspase 4 And Caspase 5 Inhibitor Acetyl Leu Glu Val Asp Cho (Mw 500.6 Da), supplied by Enzo Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/Caspase+5+Inhibitors/caspase+4+and+caspase+5+inhibitor+acetyl+leu+glu+val+asp+cho++mw+500+6+da+/pmc06930605-97-16-27
Average 90 stars, based on 1 article reviews
caspase-4 and caspase-5 inhibitor acetyl-leu-glu-val-asp-cho (mw 500.6 da) - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier
caspase-5 inhibitor drug screening kit  (RayBiotech)
N/A
Effective means for screening caspase inhibitors using fluorometric methods. (100 assays)
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caspase 5 inhibitor drug screening kit  (Fitzgerald Industries International)
N/A
Screening Kit for detection of Caspase 5 Inhibitor activity in the research laboratory
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Image Search Results


Secretion of IL-1β in response to live and UV-inactivated HCMV requires the AIM2 inflammasome. (A) Immunoblot assay for caspase-1, ASC, NLRP3, IFI16, AIM2, and GAPDH in THP-1 cells transduced with Cas9 and guide RNA (gRNA) targeting HUMCYC pseudogene or in indicated CRISPR-generated knockout cells. (B) IL-1β secretion in THP-1 cells with the HUMCYC pseudogene or gene encoding an indicated protein deleted was measured following mock treatment (white) or treatment with live (gray) or UV-inactivated (black) HCMV (HCMV-TB40/E; MOI of 3) for 18 h. Values are averages ± SEM from three biological replicates. (C) IL-1β secretion in differentiated THP-1 cells following mock treatment or treatment with UV-HCMV (UV) alone or in combination with caspase-1 inhibitor (YVAD), caspase-4 inhibitor (LEVD), caspase-5 inhibitor (WEHD), or caspase-8 inhibitor (IETD) for 18 h. Values are averages ± SEM from three replicates. One-way ANOVA with Bonferroni correction was performed. **, P < 0.01.

Journal: mBio

Article Title: Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

doi: 10.1128/mBio.02510-18

Figure Lengend Snippet: Secretion of IL-1β in response to live and UV-inactivated HCMV requires the AIM2 inflammasome. (A) Immunoblot assay for caspase-1, ASC, NLRP3, IFI16, AIM2, and GAPDH in THP-1 cells transduced with Cas9 and guide RNA (gRNA) targeting HUMCYC pseudogene or in indicated CRISPR-generated knockout cells. (B) IL-1β secretion in THP-1 cells with the HUMCYC pseudogene or gene encoding an indicated protein deleted was measured following mock treatment (white) or treatment with live (gray) or UV-inactivated (black) HCMV (HCMV-TB40/E; MOI of 3) for 18 h. Values are averages ± SEM from three biological replicates. (C) IL-1β secretion in differentiated THP-1 cells following mock treatment or treatment with UV-HCMV (UV) alone or in combination with caspase-1 inhibitor (YVAD), caspase-4 inhibitor (LEVD), caspase-5 inhibitor (WEHD), or caspase-8 inhibitor (IETD) for 18 h. Values are averages ± SEM from three replicates. One-way ANOVA with Bonferroni correction was performed. **, P < 0.01.

Article Snippet: Caspase-1 inhibitor carboxybenzoxy-Tyr-Val-Ala-Asp-fluoromethylketone (Z-YVAD-FMK), capase-4 inhibitor carboxybenzoxy-Leu-Glu-Val-Asp-fluoromethylketone (Z-LEVD-FMK), caspase-5 inhibitor carboxybenzoxy-Trp-Glu-His-Asp-fluoromethylketone (Z-WEHD-FMK), and caspase-8 inhibitor carboxybenzoxy-Ile-Glu-Thr-Asp-fluoromethylketone (Z-IETD-FMK) were all obtained from Enzo Life Science and used at a concentration of 2 μM.

Techniques: Western Blot, Transduction, CRISPR, Generated, Knock-Out